Mast cell tumours (MCT) are the most common type of skin cancer we see in dogs and on a gender-adjusted basis, the most common cancer we see in dogs. They arise in three general locations in dogs (1) cutaneous or skin (2) subcutaneous or under skin (3) mucosal derived or the lining of the mouth or vagina. The cutaneous site is the most common. The majority of dogs with MCT are curable with surgery but some do have a more aggressive form of the disease and require chemotherapy.